Well I had an S and now own a Senna which is the same engine/brakes as the R.
I can tell you that there are noticeable differences in engine response and braking.
The engine is crispier faster in response and I personally feel it torquier. And brake wise is from earth to heaven comparison.
From the spongy feeling of the Nissin 6 piston brakes to the very trustworthy brembos.
Enjoy your new R!!!