I've fitted the moto-one chip to my Brutale. My Brutale has a few extras but you need to get a chip that will fit your particular setup. Installing it was not difficult, you have to take the tank off (watch those fuel connectors if you haven't replaced them with metal ones). Also it's a good idea to modify the fuel richness whilst you're inside the ECU, make sure you use a ceramic screwdriver though to avoid any shorting out.
As far as differences to how the bike runs.. mine's leaner now (it was very rich from the factory), puts out a little bit more HP, sounds nicer on the overrun thanks to running leaner, but most importantly.. gets me 50km more out of a tank.
There's a bucketload of info available in both the FAQ (check the links section) and the moto-one website.
I got the Arrow mid-pipe and a chip from Moto One in AUS (Brad Black who's on this forum every now and then). Piece of cake to install. No flat spots, the abruptness when opening the closed throttle is virtually gone and I get about 35 MPG. Piece of cake. As Vlad pointed out, be careful with the fuel lines and as with any chip, use appropriate care with that as well.
I was out on the MV today and was thinking how good and smooth it was running. I installed a MotoOne MVB02 chip from Aus over a year ago. The detailed instructions, TPS setting and other fine tuning details made it a easy go. Well worth it - no issues at all, smooth and better fuel mileage. I have a mid pipe and BMC air filter as well.
I installed a stage 1 eprom chip from FBF last night. bike seems to run MUCH smoother. I personally, loved the jerkiness it had before, but i'd heard so many people say i should get a tuned eprom w/my setup (arrow mid pipe & shorty thunder & BMC air filter) that i figured i'd just buy one. they're only $170 shipped from ferracci. plugged it in, bike started right up after put back together. my bike was stalling quite a bit before. too early to tell if it's fixed the stalling.